2020–21 Women's LEN Trophy

The 2020–21 Women's LEN Trophy is the 21st edition of the European second-tier tournament for women's water polo clubs. It was a Final Four that was played in Barcelona, Spain, on the 17 and 18 April 2021. Kinef Kirishi of Russia won its first LEN Trophy, beating CN Mataró of Spain 10–8 in the Final.

Teams
The participants were the four teams eliminated from the Euro League's quarterfinals.

Final Four
The referees for the Final Four were: Varkony (HUN), Markopoulou (GRE), Schwartz (ISR), Ohme (GER).

Bracket
 