2021–22 Cal Poly Mustangs men's basketball team

The 2021–22 Cal Poly Mustangs men's basketball team represented California Polytechnic State University in the 2021–22 NCAA Division I men's basketball season. The Mustangs, led by third-year head coach John Smith, played their home games at the Robert A. Mott Athletics Center in San Luis Obispo, California, and competed as members of the Big West Conference.

Roster
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Schedule and results
!colspan=12 style=| Exhibition

!colspan=12 style=| Non-conference regular season

!colspan=12 style=| Big West regular season

!colspan=12 style=| Big West tournament

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