2021–22 Macedonian Handball Super League

The 2021–22 Macedonian Handball Super League was the 30th season of the Super League, North Macedonia's premier handball league. It ram from 12 September 2021 to 3 June 2022.

Vardar won their fifteenth title.

Arenas and locations
The following 12 clubs compete in the Super League during the 2021–22 season:

Promotion/relegation play-offs
The 11th-placed teams of the Macedonian Super League faces the 4th-placed team of the Group B in Macedonian First League.

Skopje 2020 won the 28–27 int these match, and therefore both clubs remain in their respective leagues.
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