2021–22 South Alabama Jaguars women's basketball team

The 2021–22 South Alabama Jaguars women's basketball team represented the University of South Alabama during the 2021–22 NCAA Division I women's basketball season. The basketball team, led by eighth-year head coach Terry Fowler, played all home games at the Mitchell Center along with the South Alabama Jaguars men's basketball team. They were members of the Sun Belt Conference.

Schedule and results
!colspan=9 style=| Exhibition

!colspan=9 style=| Non-conference Regular Season

!colspan=9 style=| Conference Regular Season

!colspan=9 style=| Sun Belt Tournament