2021–22 USC Trojans men's basketball team

The 2021–22 USC Trojans men's basketball team represented the University of Southern California during the 2021–22 NCAA Division I men's basketball season. The Trojans are led by 9th-year head coach Andy Enfield and played their home games at the Galen Center for the 16th season in Los Angeles as members of the Pac-12 Conference. They finished the season 26–8, 14–6 in Pac-12 Play to finish in third place. As the No. 3 seed in the Pac-12 tournament, they defeated Washington in the quarterfinals before losing in the semifinals to UCLA. They received an at-large bid to the NCAA tournament as the No. 7 seed in the Midwest Region, where they lost in the First Round to Miami (FL).

Previous season
The USC Trojans finished the 2020–21 season with a 25–8 overall record, and a 15–5 conference record. They finished in second place in the Pac-12 Conference. They were a part of the Pac-12 tournament they played against the Utah in the Quarterfinals and won in 2OT by the score of 91–85, they would move on to the semifinals but would lose to Colorado and would be eliminated from the tournament. They would then be invited to compete in the 2021 NCAA tournament and would get wins against Drake, Kansas, Oregon, but would then be eliminated by the Gonzaga Bulldogs in the Elite Eight.

Schedule and results
!colspan=9 style=| Regular season

!colspan=9 style=| Pac-12 Tournament

!colspan=9 style=| NCAA tournament

Source:

No.24 USC Trojans vs Saint Joseph's Hawks
Wooden Legacy semifinals

No. 24 USC Trojans vs San Diego State Aztecs
Wooden Legacy Championship Game

Oklahoma State

 * Notes: Game with Oklahoma State on December 21 was Canceled due to COVID-19 Issues.

Arizona State and No. 9 Arizona

 * Notes: Games with Arizona State on December 30 and No. 9 Arizona on January 2 were postponed due to COVID-19 Issues and will be rescheduled.

Rankings
* AP does not release post-NCAA Tournament rankings. ^Coaches did not release a Week 1 poll.