2021 Biella Challenger Indoor – Singles

This was the first of seven editions of the tournament in the 2021 tennis season.

Unseeded Illya Marchenko won the title after defeating the top seed Andy Murray 6–2, 6–4 in the final.

Seeds
• # 🇬🇧 Andy Murray (final)

• # 🇮🇹 Federico Gaio (semifinals)

• # 🇪🇬 Mohamed Safwat (second round)

• # 🇮🇹 Lorenzo Giustino (quarterfinals)

• # 🇸🇰 Martin Kližan (first round)

• # Blaž Rola (quarterfinals)

• # 🇸🇰 Filip Horanský (second round)

• # 🇰🇿 Dmitry Popko (second round)