2021 Bucharest Challenger – Singles

This was the first edition of the tournament.

Jiří Lehečka won the title after defeating Filip Horanský 6–3, 6–2 in the final.

Seeds
• # 🇮🇹 Stefano Travaglia (semifinals)

• # 🇲🇩 Radu Albot (second round)

• # 🇦🇺 Thanasi Kokkinakis (quarterfinals)

• # 🇨🇿 Zdeněk Kolář (first round)

• # 🇮🇳 Sumit Nagal (first round)

• # 🇩🇪 Maximilian Marterer (second round)

• # 🇨🇿 Vít Kopřiva (second round)

• # 🇨🇿 Jiří Lehečka (champion)