2021 Copa Sevilla – Singles

Alejandro Davidovich Fokina was the defending champion but chose not to defend his title.

Pedro Martínez won the title after defeating Roberto Carballés Baena 6–4, 6–1 in the final.

Seeds
• # 🇪🇸 Pablo Andújar (quarterfinals)

• # 🇪🇸 Pedro Martínez (champion)

• # 🇪🇸 Roberto Carballés Baena (final)

• # 🇪🇸 Carlos Taberner (semifinals)

• # 🇪🇸 Bernabé Zapata Miralles (second round)

• # 🇮🇹 Federico Gaio (second round)

• # Marcelo Tomás Barrios Vera (semifinals)

• # 🇮🇹 Lorenzo Giustino (first round)