2021 Multishow Brazilian Music Award

The 2021 Multishow Brazilian Music Award (Prêmio Multishow de Música Brasileira 2021) (or simply Multishow Award 2021) (Portuguese: Prêmio Multishow 2021) was held on December 8, 2021, at the Jeunesse Arena in Rio de Janeiro, Brazil. Singer Iza and television presenter Tatá Werneck hosted the show.

The nominations were reveled on October 18, 2021. Anitta led the nominations with five. Marina Sena received the most awards with three.

Winners and nominees
The nominees for Duo of the Year were announced on October 16, 2021, on Altas Horas. The next day, the nominees for Hit of the Year and Performance of the Year were revealed. The complete list of nominees was announced on October 18, 2021. Anitta led the nominations with five, followed by Luísa Sonza and Marina Sena with four each, while Israel & Rodolffo, João Gomes, and Luan Santana received three nominations each. On November 7, 2021, it was announced that the category Female Singer of the Year had its voting canceled. Due to Marília Mendonça death, the other nominees decided, together, to give up competing in the category and give the award to her as a way to honor her posthumously. Marina Sena was the most awarded artist of the night, winning three awards. Winners appear first and highlighted in bold.

Voted categories
The winners of the following categories were chosen by fan votes.

Professional categories
The winners of the following categories were chosen by Multishow Award Academy.