2021 Nottingham Trophy – Women's singles

Kristýna Plíšková was the defending champion, winning the last edition of the tournament in 2014, however she chose not to participate.

Alison Van Uytvanck won the title, defeating Arina Rodionova in the final, 6–0, 6–4.

Seeds
• # 🇧🇪 Alison Van Uytvanck (champion)

• # 🇯🇵 Nao Hibino (first round)

• # 🇰🇿 Zarina Diyas (first round, retired)

• # 🇺🇸 Christina McHale (first round)

• # 🇨🇳 Zhu Lin (first round)

• # 🇮🇹 Sara Errani (second round)

• # 🇧🇬 Viktoriya Tomova (first round)

• # 🇭🇺 Tímea Babos (second round)