2021 PBA 3x3 season – Third conference

The third conference of the 2021 PBA 3x3 season started on May 21, 2022, and ended on July 3, 2022. It consisted of six two-day legs and a grand final. TNT Tropang Giga became the conference's Grand Champion after defeating Purefoods TJ Titans in the Grand Finals, 21–19.

Teams
The players listed have played in at least one of the legs. The Zamboanga Valienters returned this conference after taking a leave of absence during the second conference.

Groupings
The preliminary drawing of lots was held on May 18, 2022.

Knockout stage
TNT Tropang Giga defeated Barangay Ginebra San Miguel in the finals, 18–15, to become the first leg winners.

Final standings
Source: PBA 3x3

Knockout stage
Meralco Bolts 3x3 defeated Cavitex Braves in the finals, 18–17, to become the second leg winners.

Final standings
Source: PBA 3x3

Knockout stage
TNT Tropang Giga defeated Purefoods TJ Titans in the finals, 21–13, to become the third leg winners.

Final standings
Source: PBA 3x3

Knockout stage
TNT Tropang Giga defeated Terrafirma 3x3 in the finals, 21–15, to win the fourth leg and repeat as leg winners.

Final standings
Source: PBA 3x3

Knockout stage
San Miguel Beermen defeated TNT Tropang Giga in the finals, 21–12, to become the fifth leg winners and deny TNT a three-peat of leg wins.

Final standings
Source: PBA 3x3

Final standings
Source: PBA 3x3

Legs summary
Source: PBA 3x3

Bracket
Seed refers to the position of the team after six legs. Letter and number inside parentheses denotes the pool letter and pool position of the team, respectively, after the preliminary round of the Grand Finals.