2021 San Jose State Spartans football team

The 2021 San Jose State Spartans football team represented San José State University in the 2021 NCAA Division I FBS football season. The Spartans were led by fifth–year head coach Brent Brennan and played their home games at CEFCU Stadium. They were members of the West Division of the Mountain West Conference.

Linebacker Kyle Harmon ranked second nationally with 133 total tackles (72 unassisted, 61 assisted) during the 2021 season.