2021 San Marino Open – Doubles

Radu Albot and Enrique López Pérez were the defending champions but chose not to defend their title.

Zdeněk Kolář and Luis David Martínez won the title after defeating Rafael Matos and João Menezes 1–6, 6–3, [10–3] in the final.

Seeds
• # 🇬🇧 Lloyd Glasspool / 🇬🇧 Jonny O'Mara (first round)

• # 🇫🇮 Harri Heliövaara / 🇦🇺 Matt Reid (first round)

• # 🇧🇷 Orlando Luz / 🇧🇷 Felipe Meligeni Alves (quarterfinals)

• # 🇨🇿 Zdeněk Kolář / 🇻🇪 Luis David Martínez (champions)