2021 Vanderbilt Commodores football team

The 2021 Vanderbilt Commodores football team represented Vanderbilt University in the 2021 NCAA Division I FBS football season. The Commodores played their home games at Vanderbilt Stadium in Nashville, Tennessee and competed in the Eastern Division of the Southeastern Conference (SEC). They were led by first-year head coach Clark Lea.

East Tennessee State
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At Colorado State
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Stanford
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No. 2 Georgia
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UConn
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At No. 20 Florida
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At South Carolina
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Mississippi State
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Missouri
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Kentucky
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At No. 12 Ole Miss
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At Tennessee
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