2021 Vesuvio Cup – Singles

This was the first edition of the tournament.

Tallon Griekspoor won the title after defeating Alexander Ritschard 6–3, 6–2 in the final.

Seeds
• # 🇦🇷 Federico Coria (second round)

• # 🇮🇹 Marco Cecchinato (second round)

• # 🇫🇷 Hugo Gaston (first round)

• # 🇸🇰 Alex Molčan (withdrew)

• # Tallon Griekspoor (champion)

• # 🇸🇰 Andrej Martin (second round)

• # 🇪🇸 Bernabé Zapata Miralles (quarterfinals)

• # 🇩🇪 Yannick Hanfmann (second round)