2022–23 Wyoming Cowgirls basketball team

The 2022–23 Wyoming Cowgirls basketball team represented the University of Wyoming in the 2022–23 college basketball season. The Cowgirls were led by head coach Heather Ezell, in her first season. The Cowgirls played their home games at the Arena-Auditorium, and were members of the Mountain West Conference. The Cowgirls finished 2nd in the Mountain West Conference, and lost in the championship game of the Mountain West Conference Women's Basketball tournament to UNLV 71–60. The Cowgirls were invited to the WNIT, and lost in the 2nd round to Kansas State 71–55.

Previous season
The Cowgirls finished the 2021–22 season 17–13, 11–6 in Mountain West play to finish tied for third place in the conference. They lost in the quarterfinal round of the Mountain West Conference Women's Basketball tournament to Colorado State. Head coach Gerald Mattinson announced his retirement from coaching at the conclusion of the season, and Heather Ezell was hired as the new head coach the same day.

Schedule
!colspan=9 style=| Exhibition

!colspan=9 style=| Non–Conference

!colspan=9 style=| Mountain West Conference

!colspan=9 style=| Mountain West Women's Tournament

!colspan=9 style=| WNIT