2022 Angelo State Rams football team

The 2022 Angelo State Rams football represented Angelo State University as a member of the Lone Star Conference during the 2022 NCAA Division II football season. Led by fifth-year head coach Jeff Girsch, the Rams compiled an overall record of 12–1 with a mark of 9–0 in conference play, winning the LSC title. Angelo State received a first-round bye in the NCAA Division II Football Championship playoffs and beat in the second round before losing to Colorado Mines in the quarterfinals. Angelos State played home games at the LeGrand Sports Complex in San Angelo, Texas.