2022 Calgary National Bank Challenger – Men's singles

Arthur Rinderknech was the defending champion but chose not to defend his title.

Dominik Koepfer won the title after defeating Aleksandar Vukic 6–2, 6–4 in the final.

Seeds
• # 🇪🇨 Emilio Gómez (first round)

• # 🇨🇦 Vasek Pospisil (quarterfinals)

• # 🇦🇷 Juan Pablo Ficovich (second round)

• # 🇦🇺 Aleksandar Vukic (final)

• # 🇩🇪 Dominik Koepfer (champion)

• # 🇫🇷 Antoine Escoffier (quarterfinals)

• # 🇺🇸 Brandon Holt (first round)

• # 🇨🇦 Alexis Galarneau (quarterfinals)