2022 Cleveland Open – Singles

Bjorn Fratangelo was the defending champion but lost in the first round to Nicola Kuhn.

Dominic Stricker won the title after defeating Yoshihito Nishioka 7–5, 6–1 in the final.

Seeds
• # 🇺🇸 Tennys Sandgren (second round)

• # 🇮🇹 Andreas Seppi (first round)

• # 🇯🇵 Yoshihito Nishioka (final)

• # 🇬🇧 Liam Broady (second round)

• # 🇦🇹 Jurij Rodionov (second round)

• # 🇺🇸 Ernesto Escobedo (quarterfinals)

• # 🇪🇨 Emilio Gómez (second round, retired)

• # 🇺🇸 Jack Sock (second round, retired)