2022 Empire Women's Indoor 2 – Singles

Jaqueline Cristian was the defending champion but chose not to participate.

Eva Lys won the title, defeating Anna Karolína Schmiedlová in the final, 6–2, 4–6, 6–2.

Seeds
• # 🇨🇿 Linda Nosková (quarterfinals)

• # 🇸🇰 Anna Karolína Schmiedlová (final)

• # 🇺🇦 Daria Snigur (first round)

• # Vitalia Diatchenko (quarterfinals)

• # 🇬🇧 Katie Swan (withdrew)

• # 🇫🇷 Léolia Jeanjean (second round)

• # 🇺🇸 Caty McNally (semifinals)

• # 🇩🇪 Eva Lys (champion)