2022 Nottingham Open – Men's singles

Frances Tiafoe was the defending champion but chose not to defend his title.

Dan Evans won the title after defeating Jordan Thompson 6–4, 6–4 in the final.

Seeds
• # 🇬🇧 Dan Evans (champion)

• # 🇨🇿 Jiří Veselý (first round)

• # 🇦🇺 Jordan Thompson (final)

• # 🇦🇺 John Millman (first round)

• # 🇦🇺 Alexei Popyrin (semifinals)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇺🇸 Jack Sock (semifinals)

• # Marc-Andrea Hüsler (quarterfinals)