2022 Open Comunidad de Madrid – Singles

This was the first edition of the tournament.

Pedro Cachin won the title after defeating Marco Trungelliti 6–3, 6–7(3–7), 6–3 in the final.

Seeds
• # 🇪🇸 Roberto Carballés Baena (semifinals)

• # 🇧🇷 Thiago Monteiro (semifinals)

• # 🇪🇸 Feliciano López (first round, withdrew)

• # 🇪🇸 Fernando Verdasco (second round)

• # 🇩🇪 Mats Moraing (second round)

• # 🇫🇷 Lucas Pouille (quarterfinals)

• # Tseng Chun-hsin (withdrew)

• # 🇷🇸 Nikola Milojević (first round)

• # 🇦🇺 Christopher O'Connell (quarterfinals)