2022 Open Harmonie mutuelle – Singles

Kamil Majchrzak was the defending champion but chose not to defend his title.

Jack Draper won the title after defeating Zizou Bergs 6–2, 5–7, 6–4 in the final.

Seeds
• # 🇱🇹 Ričardas Berankis (withdrew)

• # 🇫🇷 Quentin Halys (semifinals)

• # 🇫🇷 Gilles Simon (first round)

• # Roman Safiullin (second round, withdrew)

• # 🇬🇧 Jack Draper (champion)

• # 🇫🇷 Grégoire Barrère (first round)

• # 🇫🇷 Constant Lestienne (first round, retired)

• # 🇫🇷 Antoine Hoang (second round)