2022 Open Sopra Steria de Lyon – Singles

Pablo Cuevas was the defending champion but chose not to defend his title.

Corentin Moutet won the title after defeating Pedro Cachin 6–4, 6–4 in the final.

Seeds
• # 🇦🇷 Federico Coria (quarterfinals)

• # 🇫🇷 Richard Gasquet (semifinals)

• # 🇧🇴 Hugo Dellien (first round)

• # 🇪🇸 Pablo Andújar (first round)

• # Nuno Borges (second round)

• # Tomás Barrios Vera (withdrew)

• # 🇫🇷 Corentin Moutet (champion)

• # 🇫🇷 Manuel Guinard (semifinals)