2022 Rafa Nadal Open – Singles

Lukáš Lacko was the defending champion but retired in the final round of qualifying in his match against Daniil Glinka.

Luca Nardi won the title after defeating Zizou Bergs 7–6(7–2), 3–6, 7–5 in the final.

Seeds
• # Dominic Stricker (first round)

• # 🇬🇧 Ryan Peniston (second round)

• # 🇦🇺 Aleksandar Vukic (second round)

• # 🇧🇪 Zizou Bergs (final)

• # 🇫🇷 Grégoire Barrère (first round, retired)

• # 🇯🇵 Kaichi Uchida (first round)

• # 🇮🇹 Luca Nardi (champion)

• # 🇫🇷 Gilles Simon (withdrew)

• # 🇩🇪 Daniel Masur (first round)