2022 San Marcos Open Aguascalientes – Singles

This was the first edition of the tournament.

Marc-Andrea Hüsler won the title after defeating Juan Pablo Ficovich 6–4, 4–6, 6–3 in the final.

Seeds
• # 🇸🇰 Andrej Martin (first round)

• # Nicolás Jarry (quarterfinals)

• # Marc-Andrea Hüsler (champion)

• # 🇺🇸 Ernesto Escobedo (second round)

• # 🇬🇧 Jay Clarke (second round)

• # Tim van Rijthoven (first round)

• # 🇮🇹 Federico Gaio (semifinals)

• # 🇦🇷 Juan Pablo Ficovich (final)