2022 Sarasota Open – Singles

Tommy Paul was the defending champion but chose not to defend his title.

Daniel Elahi Galán won the title after defeating Steve Johnson 7–6(9–7), 4–6, 6–1 in the final.

Seeds
• # 🇺🇸 Denis Kudla (semifinals)

• # 🇦🇺 Jordan Thompson (withdrew)

• # Alejandro Tabilo (semifinals)

• # 🇺🇸 Steve Johnson (final)

• # 🇨🇴 Daniel Elahi Galán (champion)

• # 🇦🇷 Juan Ignacio Londero (first round, retired)

• # 🇺🇸 Jack Sock (quarterfinals)

• # Tomás Barrios Vera (second round)