53

53 may refer to:
 * 53 (number)
 * one of the years 53 BC, AD 53, 1953, 2053
 * FiftyThree, an American privately held technology company that specializes in tools for mobile creation and visual thinking
 * 53rd Regiment Alabama Cavalry
 * 53rd Regiment of Foot (disambiguation)
 * 53rd Division (disambiguation)
 * 53 (Jacky Terrasson album), 2019
 * "Fifty Three", a song by Karma to Burn from the album Arch Stanton, 2014
 * Fifth Third Bank
 * 53 Kalypso, a main-belt asteroid