ADAMTS-4 endopeptidase

ADAMTS-4 endopeptidase (, aggrecanase-1) is an enzyme. This enzyme catalyses the following chemical reaction


 * Glutamyl endopeptidase; bonds cleaved include -Thr-Glu-Gly-Glu373-Ala-Arg-Gly-Ser- in the interglobular domain of mammalian aggrecan

This enzyme belongs to the peptidase family M12.