ARMCX6

Armadillo repeat containing X-linked 6 is a protein that in humans is encoded by the ARMCX6 gene located on the X-chromosome.

It is one of six armadillo repeats containing X-linked proteins (ARMCX1, ARMCX2, ARMCX3, ARMCX4, ARMCX5, and ARMCX6 (this protein)).

The function of this protein is unknown at this time.

Protein sequence
1 MGRAREVGWM AAGLMIGAGA CYCVYKLTIG RDDSEKLEEE 41 GEEEWDDDQE LDEEEPDIWF DFETMARPWT EDGDWTEPGA 81 PGGTEDRPSG GGKANRAHPI KQRPFPYEHK NTWSAQNCKN 121 GSCVLDLSKC LFIQGKLLFA EPKDAGFPFS QDINSHLASL 161 SMARNTSPTP DPTVREALCA PDNLNASIES QGQIKMYINE 201 VCRETVSRCC NSFLQQAGLN LLISMTVINN MLAKSASDLK 241 FPLISEGSGC AKVQVLKPLM GLSEKPVLAG ELVGAQMLFS 301 FMSLFIRNGN REILLETPAP

Homology
ARMCX6 is conserved in many eukaryotic organisms.

Secondary Structure
The secondary structure of ARMCX6 is predicted to be similar to cyanase. A comparison of the two sequences is shown below. 10       20        30        40                ....*....|....*....|....*....|....*....|....*.. ARMCX6      231 MLAKSASDLKFPLISEGSGCAKVQVLKPLMGLSEKPVLAGELVGAQM 277 1DW9_A      19 LLSKAKKDLSFAEIADGTGLAEAFVTAALLGQQALPADAARLVGAKL 65 + +  ++ +  +  + + +   +   + +    +  +  ++++



Expression
Microarray data show that ARMCX6 is highly expressed during earliest stages of spermatogenesis in mice.