Zinc-alpha-2-glycoprotein is a protein that in humans is encoded by the AZGP1gene.[5][6]
This gene expresses a soluble protein that stimulates lipolysis, induces a reduction in body fat in mice, is associated with the cachexia related to cancer, and is known to be expressed in secretory cells of lungepithelium.[7] In 2009, it was found that smoking increases expression of this gene, which is why smoking cessation leads to weight gain.[7] Zinc-alpha-2-glycoprotein levels also rise with onset of diabetes 2, which accounts for weight loss thereafter.[citation needed]
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Ueyama H, Niwa M, Tada T, Sasaki M, Ohkubo I (Jul 1991). "Cloning and nucleotide sequence of a human Zn-alpha 2-glycoprotein cDNA and chromosomal assignment of its gene". Biochem Biophys Res Commun. 177 (2): 696–703. doi:10.1016/0006-291X(91)91844-3. PMID2049092.
Freije JP, Fueyo A, Uría J, López-Otín C (1991). "Human Zn-alpha 2-glycoprotein cDNA cloning and expression analysis in benign and malignant breast tissues". FEBS Lett. 290 (1–2): 247–9. doi:10.1016/0014-5793(91)81271-9. PMID1915885. S2CID2058665.
Tada T, Ohkubo I, Niwa M, et al. (1991). "Immunohistochemical localization of Zn-alpha 2-glycoprotein in normal human tissues". J. Histochem. Cytochem. 39 (9): 1221–6. doi:10.1177/39.9.1918940. PMID1918940. S2CID687025.
Shibata S, Miura K (1982). "Nephritogenic glycoprotein. IX. Plasma Zn-alpha2-glycoprotein as a second source of nephritogenic glycoprotein in urine". Nephron. 31 (2): 170–6. doi:10.1159/000182638. PMID6896906.
Ueyama H, Deng HX, Ohkubo I (1994). "Molecular cloning and chromosomal assignment of the gene for human Zn-alpha 2-glycoprotein". Biochemistry. 32 (48): 12968–76. doi:10.1021/bi00211a004. PMID8241150.
Freije JP, Fueyo A, Uría JA, et al. (1994). "Human Zn-alpha 2-glycoprotein: complete genomic sequence, identification of a related pseudogene and relationship to class I major histocompatibility complex genes". Genomics. 18 (3): 575–87. doi:10.1016/S0888-7543(05)80359-3. PMID8307568.
Brysk MM, Lei G, Rajaraman S, et al. (1997). "Gene expression of zinc-alpha 2-glycoprotein in normal human epidermal and buccal epithelia". In Vivo. 11 (3): 271–4. PMID9239523.
Ogikubo O, Maeda T, Yamane T, et al. (1998). "Regulation of Zn-alpha2-glycoprotein-mediated cell adhesion by kininogens and their derivatives". Biochem. Biophys. Res. Commun. 252 (1): 257–62. doi:10.1006/bbrc.1998.9614. PMID9813179.