Aldehyde-stabilized cryopreservation

Aldehyde-stabilized cryopreservation is a new technique for cryopreservation first demonstrated in 2016 by Robert L. McIntyre and Gregory Fahy at the cryobiology research company 21st Century Medicine, Inc. This technique uses a particular implementation of fixation and vitrification that can successfully preserve a rabbit brain in "near perfect" condition at −135 °C, with the cell membranes, synapses, and intracellular structures intact in electron micrographs. The technique has finally won the Small Animal Brain Preservation Prize of the Brain Preservation Foundation. The cryopreserved brain was rewarmed and no serious degradation was found to have occurred; the brain structure under electron microscopic evaluation after rewarming remained well-preserved. Although this technique has not yet lead to a successful revival of a cryopreserved brain, some researchers see this technique as providing promising directions for future research.