Amos Panet

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Amos Panet
Alma materHebrew University of Jerusalem
Scientific career
Fieldsvirology, biotechnology
InstitutionsHebrew University of Jerusalem

Amos Panet is a distinguished Professor of Virology at the Hebrew University of Jerusalem.[1][2][3] His research has focused on virology and biotechnology.[1][4]

Early life[edit]

Panet was drafted into the Israeli army in 1959, where he served as a combat officer. In 1962, he began his studies at the Hebrew University of Jerusalem, majoring in biochemistry.[3] He continued his education there, earning a doctorate in biological chemistry in 1971.[1]

Research[edit]

After completing his PhD, Panet joined the laboratory of Nobel laureate Gobind Khorana at the Massachusetts Institute of Technology (MIT) as a postdoctoral fellow.[5] During his time at Khorana's lab, Panet developed pioneering methods for the chemical synthesis of DNA.[5] His research focused on developing techniques for DNA amplification using DNA polymerase and synthetic DNA primers, with significant findings published in 1974, which contributed to the subsequent development of PCR technology, which was described by Kary Mullis in 1986.[6][7][8]

Influenced by the work of Nobel laureate David Baltimore on retroviruses, Panet shifted his research focus from chemistry to virology in 1973.[9] In 1975, he joined the Hebrew University - Hadassah Medical School as a faculty member, where he has since served as a professor of virus research.[1][2]

Retrovirus research and anti-HIV drug development[edit]

As a professor at the Hebrew University of Jerusalem, Panet later investigated the mechanisms of viral replication and pathogenesis, focusing on viruses such as HIV and herpes viruses.[10][11] He also identified viral proteins that serve as targets for antiviral drugs and vaccine development.[12][13]

Career[edit]

Panet has been associated with the Hebrew University of Jerusalem since 1982.[2][9]

Director of research at BTG Corp[edit]

During his tenure, he served as the chief scientist and director of at Bio-Technology General Corp, an Israeli biotechnology company, where he contributed to the development of new drugs and vaccines.[9] During his time at BTG Corp, he contributed to the development of two FDA-approved compounds: the Human Growth Hormone and the Hepatitis B virus vaccine.[14]

Entrepreneurial career[edit]

He co-founded Medgenix, a biotech company focused on developing a new devise for the sustained release of hormones such as Erythropoietin.[9][15] Another venture initiated by Panet was Theravir, which focused on developing an oncolytic virus for cancer therapy.[16][17] He also founded Virucure Corp., which focuses on developing a modified virus as a treatment for cancer.[18]

Selected publications[edit]

  • Shapir, N., Miari, R., Blum, S., Schwartz, D., Chernin, G., Neil, G.A., Afik, D., Panet, A., Preclinical and Preliminary Clinical Evaluation of Genetically Transduced Dermal Tissue Implants for the Sustained Secretion of Erythropoietin and Interferon α, (2015) Human Gene Therapy Clinical Development, 26, 4:216-227.[19]
  • Weisblum, Y., Panet, A., Zakay-Rones, Z., Vitenshtein, A., Haimov-Kochman, R., Goldman-Wohl, D., Oiknine-Djian, E., Yamin, R., Meir, K., Amsalem, H., Imbar, ., Mandelboim, O., Yagel, S., Wolf, D.G., Human cytomegalovirus induces a distinct innate immune response in the maternal-fetal interface, (2015) Virology, 485, :289-296.[20]
  • Berger, A.A., Gil, Y., Panet, A., Weisblum, Y., Oiknine-Djian, E., Gropp, M., Steiner, D., Reubinoff, B.E., Wolf, D.G., Transition toward human cytomegalovirus susceptibility in early human embryonic stem cell-derived neural precursors, (2015) Journal of Virology, 89, 21:11159-11164.[21]
  • Tsalenchuck, Y., Steiner, I., Panet, A., Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain, (2016) Journal of NeuroVirology, 22, 5:641-649.[22]
  • Weisblum, Y., Oiknine-Djian, E., Zakay-Rones, Z., Vorontsov, O., Haimov-Kochman, R., Nevo, Y., Stockheim, D., Yagel, S., Panet, A., Wolf, D.G., APOBEC3A is upregulated by human cytomegalovirus (HCMV) in the maternal-fetal interface, acting as an innate anti-HCMV effector, (2017) Journal of Virology, 91, 23.[23]
  • Glasner, A., Oiknine-Djian, E., Weisblum, Y., Diab, M., Panet, A., Wolf, D.G., Mandelboim, O., Zika virus escapes NK cell detection by upregulating major histocompatibility complex class I molecules, (2017) Journal of Virology, 91, 22.[24]
  • Zafir-Lavie, I., Miari, R., Sherbo, S., Krispel, S., Tal, O., Liran, A., Shatil, T., Badinter, F., Goltsman, H., Shapir, N., Benhar, I., Neil, G.A., Panet, A., Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis, (2017) Journal of Gene Medicine, 19, 8.[25]
  • Weisblum, Y., Oiknine-Djian, E., Vorontsov, O.M., Haimov-Kochman, R., Zakay-Rones, Z., Meir, K., Shveiky, D., Elgavish, S., Nevo, Y., Roseman, M., Bronstein, M., Stockheim, D., From, I., Eisenberg, I., Lewkowicz, A.A., Yagel, S., Panet, A., Wolf, D.G., Zika virus infects early- and midgestation human maternal decidual tissues, inducing distinct innate tissue responses in the maternal-fetal interface, (2017) Journal of Virology, 91, 4.[26]
  • Zafir-Lavie, I., Sherbo, S., Goltsman, H., Badinter, F., Yeini, E., Ofek, P., Miari, R., Tal, O., Liran, A., Shatil, T., Krispel, S., Shapir, N., Neil, G.A., Benhar, I., Panet, A., Satchi-Fainaro, R., Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases, (2018) Journal of Controlled Release, 291, :80-89.[27]
  • Oiknine-Djian, E., Weisblum, Y., Panet, A., Wong, H.N., Haynes, R.K., Wolfa, D.G., The artemisinin derivative artemisone is a potent inhibitor of human cytomegalovirus replication, (2018) Antimicrobial Agents and Chemotherapy, 62, 7.[28]
  • Oiknine-Djian, E., Bar-On, S., Laskov, I., Lantsberg, D., Haynes, R.K., Panet, A., Wolf, D.G., Artemisone demonstrates synergistic antiviral activity in combination with approved and experimental drugs active against human cytomegalovirus, (2019) Antiviral Research, 172.[29]
  • Alfi, O., From, I., Yakirevitch, A., Drendel, M., Wolf, M., Meir, K., Zakay-Rones, Z., Nevo, Y., Elgavish, S., Ilan, O., Weisblum, Y., Tayeb, S., Gross, M., Jonas, W., Ives, J., Oberbaum, M., Panet, A., Wolf, D.G., Human Nasal Turbinate Tissues in Organ Culture as a Model for Human Cytomegalovirus Infection at the Mucosal Entry Site, (2020) Journal of virology, 94, 19.[30]
  • Personal life

Personal life[edit]

Panet is married to Rivka and has three children and eleven grandchildren.[31]

References[edit]

  1. ^ a b c d "Prof. Amos Panet". medicine.ekmd.huji.ac.il. Retrieved 2024-05-05.
  2. ^ a b c "Amos Panet". en.huji.ac.il. Retrieved 2024-05-05.
  3. ^ a b "Prof. Amos Panet". BFHU. Retrieved 2024-05-05.
  4. ^ Index, AD Scientific. "Amos Panet - AD Scientific Index 2024". www.adscientificindex.com. Retrieved 2024-05-05.
  5. ^ a b Panet, Amos; Khorana, H. Gobind (1974). "Studies on Polynucleotides". Journal of Biological Chemistry. 249 (16): 5213–5221. doi:10.1016/s0021-9258(19)42350-8. ISSN 0021-9258.
  6. ^ Khorana, H G; Agarwal, K L; Besmer, P; Büchi, H; Caruthers, M H; Cashion, P J; Fridkin, M; Jay, E; Kleppe, K; Kleppe, R; Kumar, A; Loewen, P C; Miller, R C; Minamoto, K; Panet, A (1976). "Total synthesis of the structural gene for the precursor of a tyrosine suppressor transfer RNA from Escherichia coli. 1. General introduction". Journal of Biological Chemistry. 251 (3): 565–570. doi:10.1016/s0021-9258(17)33826-7. ISSN 0021-9258.
  7. ^ Panet, Amos; Khorana, H. Gobind (1974). "Studies on Polynucleotides". Journal of Biological Chemistry. 249 (16): 5213–5221. doi:10.1016/s0021-9258(19)42350-8. ISSN 0021-9258.
  8. ^ Tomar, Sonia (2018-05-01). "Polymerase Chain Reaction and ITS Clinical Application: A Review". Journal of Pharmaceutical & Scientific Innovation. 7 (1): 14–19. doi:10.7897/2277-4572.07175. ISSN 2277-4572.
  9. ^ a b c d "Amos Panet".
  10. ^ Ganesh, Lakshmanan; Leung, Kwanyee; Loré, Karin; Levin, Reuven; Panet, Amos; Schwartz, Owen; Koup, Richard A.; Nabel, Gary J. (2004). "Infection of Specific Dendritic Cells by CCR5-Tropic Human Immunodeficiency Virus Type 1 Promotes Cell-Mediated Transmission of Virus Resistant to Broadly Neutralizing Antibodies". Journal of Virology. 78 (21): 11980–11987. doi:10.1128/JVI.78.21.11980-11987.2004. ISSN 0022-538X. PMC 523246. PMID 15479838.
  11. ^ Haim, Hillel; Steiner, Israel; Panet, Amos (2005). "Synchronized Infection of Cell Cultures by Magnetically Controlled Virus". Journal of Virology. 79 (1): 622–625. doi:10.1128/JVI.79.1.622-625.2005. ISSN 0022-538X. PMC 538731. PMID 15596857.
  12. ^ Matza-Porges, Sigal; Tavor, Einat; Panet, Amos; Honigman, Alik (2003). "Intracellular expression of a functional short peptide confers resistance to apoptosis". Experimental Cell Research. 290 (1): 60–67. doi:10.1016/s0014-4827(03)00306-9. ISSN 0014-4827. PMID 14516788.
  13. ^ Weisblum, Yiska; Panet, Amos; Zakay-Rones, Zichria; Haimov-Kochman, Ronit; Goldman-Wohl, Debra; Ariel, Ilana; Falk, Haya; Natanson-Yaron, Shira; Goldberg, Miri D.; Gilad, Ronit; Lurain, Nell S.; Greenfield, Caryn; Yagel, Simcha; Wolf, Dana G. (2011-12-15). "Modeling of Human Cytomegalovirus Maternal-Fetal Transmission in a Novel Decidual Organ Culture". Journal of Virology. 85 (24): 13204–13213. doi:10.1128/JVI.05749-11. ISSN 0022-538X. PMC 3233115. PMID 21976654.
  14. ^ "History". Bio-Technology General Israel. Retrieved 2024-05-29.
  15. ^ "Coronavirus: How Easy Will It Be to Develop Drugs and Vaccines". BFHU. Retrieved 2024-05-05.
  16. ^ "Viruses: The new cancer hunters". IsraCast. 2006-02-28. Retrieved 2024-05-05.
  17. ^ "Amos Panet Inventions, Patents and Patent Applications - Justia Patents Search". patents.justia.com. Retrieved 2024-05-05.
  18. ^ "ViruCure Therapeutics". finder.startupnationcentral.org. Retrieved 2024-05-29.
  19. ^ Shapir, Nir; Miari, Reem; Blum, Shany; Schwartz, Doron; Chernin, Gil; Neil, Garry A.; Afik, Daniel; Panet, Amos (2015). "Preclinical and Preliminary Clinical Evaluation of Genetically Transduced Dermal Tissue Implants for the Sustained Secretion of Erythropoietin and Interferon α". Human Gene Therapy Clinical Development. 26 (4): 216–227. doi:10.1089/humc.2015.125. ISSN 2324-8637. PMID 26684446.
  20. ^ Weisblum, Yiska; Panet, Amos; Zakay-Rones, Zichria; Vitenshtein, Alon; Haimov-Kochman, Ronit; Goldman-Wohl, Debra; Oiknine-Djian, Esther; Yamin, Rachel; Meir, Karen; Amsalem, Hagai; Imbar, Tal; Mandelboim, Ofer; Yagel, Simcha; Wolf, Dana G. (2015-11-01). "Human cytomegalovirus induces a distinct innate immune response in the maternal–fetal interface". Virology. 485: 289–296. doi:10.1016/j.virol.2015.06.023. ISSN 0042-6822. PMID 26318261.
  21. ^ Berger, Amnon A.; Gil, Yaniv; Panet, Amos; Weisblum, Yiska; Oiknine-Djian, Esther; Gropp, Michal; Steiner, Debora; Reubinoff, Benjamin E.; Wolf, Dana G. (2015). Longnecker, R. M. (ed.). "Transition toward Human Cytomegalovirus Susceptibility in Early Human Embryonic Stem Cell-Derived Neural Precursors". Journal of Virology. 89 (21): 11159–11164. doi:10.1128/JVI.01742-15. ISSN 0022-538X. PMC 4621109. PMID 26292329.
  22. ^ Tsalenchuck, Yael; Steiner, Israel; Panet, Amos (2016-10-01). "Innate defense mechanisms against HSV-1 infection in the target tissues, skin and brain". Journal of NeuroVirology. 22 (5): 641–649. doi:10.1007/s13365-016-0440-9. ISSN 1538-2443. PMID 27098517.
  23. ^ Weisblum, Yiska; Oiknine-Djian, Esther; Zakay-Rones, Zichria; Vorontsov, Olesya; Haimov-Kochman, Ronit; Nevo, Yuval; Stockheim, David; Yagel, Simcha; Panet, Amos; Wolf, Dana G. (2017). Jung, Jae U. (ed.). "APOBEC3A Is Upregulated by Human Cytomegalovirus (HCMV) in the Maternal-Fetal Interface, Acting as an Innate Anti-HCMV Effector". Journal of Virology. 91 (23). doi:10.1128/JVI.01296-17. ISSN 0022-538X. PMC 5686750. PMID 28956761.
  24. ^ Glasner, Ariella; Oiknine-Djian, Esther; Weisblum, Yiska; Diab, Mohammad; Panet, Amos; Wolf, Dana G.; Mandelboim, Ofer (2017-11-15). Diamond, Michael S. (ed.). "Zika Virus Escapes NK Cell Detection by Upregulating Major Histocompatibility Complex Class I Molecules". Journal of Virology. 91 (22). doi:10.1128/JVI.00785-17. ISSN 0022-538X. PMC 5660495. PMID 28878071.
  25. ^ Zafir-Lavie, Inbal; Miari, Reem; Sherbo, Shay; Krispel, Simi; Tal, Osnat; Liran, Atar; Shatil, Tamar; Badinter, Felix; Goltsman, Haim; Shapir, Nir; Benhar, Itai; Neil, Garry A.; Panet, Amos (2017). "Sustained secretion of anti-tumor necrosis factor α monoclonal antibody from ex vivo genetically engineered dermal tissue demonstrates therapeutic activity in mouse model of rheumatoid arthritis". The Journal of Gene Medicine. 19 (8). doi:10.1002/jgm.2965. ISSN 1099-498X.
  26. ^ Weisblum, Yiska; Oiknine-Djian, Esther; Vorontsov, Olesya M.; Haimov-Kochman, Ronit; Zakay-Rones, Zichria; Meir, Karen; Shveiky, David; Elgavish, Sharona; Nevo, Yuval; Roseman, Moshe; Bronstein, Michal; Stockheim, David; From, Ido; Eisenberg, Iris; Lewkowicz, Aya A. (2017-02-15). Perlman, Stanley (ed.). "Zika Virus Infects Early- and Midgestation Human Maternal Decidual Tissues, Inducing Distinct Innate Tissue Responses in the Maternal-Fetal Interface". Journal of Virology. 91 (4). doi:10.1128/JVI.01905-16. ISSN 0022-538X. PMC 5286880. PMID 27974560.
  27. ^ Zafir-Lavie, Inbal; Sherbo, Shay; Goltsman, Haim; Badinter, Felix; Yeini, Eilam; Ofek, Paula; Miari, Reem; Tal, Osnat; Liran, Atar; Shatil, Tamar; Krispel, Simi; Shapir, Nir; Neil, Garry A.; Benhar, Itai; Panet, Amos (2018-12-10). "Successful intracranial delivery of trastuzumab by gene-therapy for treatment of HER2-positive breast cancer brain metastases". Journal of Controlled Release. 291: 80–89. doi:10.1016/j.jconrel.2018.10.017. ISSN 0168-3659. PMID 30342077.
  28. ^ Oiknine-Djian, E.; Weisblum, Y.; Panet, A.; Wong, H. N.; Haynes, R. K.; Wolf, D. G. (2018). "The Artemisinin Derivative Artemisone Is a Potent Inhibitor of Human Cytomegalovirus Replication". Antimicrobial Agents and Chemotherapy. 62 (7). doi:10.1128/AAC.00288-18. ISSN 0066-4804. PMC 6021623. PMID 29712656.
  29. ^ Oiknine-Djian, Esther; Bar-On, Shikma; Laskov, Ido; Lantsberg, Daniel; Haynes, Richard K.; Panet, Amos; Wolf, Dana G. (2019-12-01). "Artemisone demonstrates synergistic antiviral activity in combination with approved and experimental drugs active against human cytomegalovirus". Antiviral Research. 172: 104639. doi:10.1016/j.antiviral.2019.104639. ISSN 0166-3542.
  30. ^ Alfi, Or; From, Ido; Yakirevitch, Arkadi; Drendel, Michael; Wolf, Michael; Meir, Karen; Zakay-Rones, Zichria; Nevo, Yuval; Elgavish, Sharona; Ilan, Ophir; Weisblum, Yiska; Tayeb, Shay; Gross, Menachem; Jonas, Wayne; Ives, John (2020-09-15). Goodrum, Felicia (ed.). "Human Nasal Turbinate Tissues in Organ Culture as a Model for Human Cytomegalovirus Infection at the Mucosal Entry Site". Journal of Virology. 94 (19). doi:10.1128/JVI.01258-20. ISSN 0022-538X. PMC 7495380. PMID 32727881.
  31. ^ Panet, Rivka; Amir, Iris; Snyder, David; Zonenshein, Leora; Atlan, Henri; Laskov, Reuven; Panet, Amos (1989). "Effect of Na + flux inhibitors on induction of c-fos, c-myc, and ODC genes during cell cycle". Journal of Cellular Physiology. 140 (1): 161–168. doi:10.1002/jcp.1041400119. ISSN 0021-9541. PMID 2472417.

External links[edit]

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