CCDC90B

Coiled coil domain containing 90B, also known as CCDC90B, is a protein encoded by the CCDC90B gene.

Gene
CCDC90B is located on chromosome 11 in humans. It is neighbored by:
 * PCF11, a mammalian pre-mRNA cleavage complex 2 protein
 * ANKRD42, ankyrin repeat protein involved with calcium ion bonding
 * BC070093
 * DLG2, a member of the membrane-associated guanylate kinase (MAGUK) family

Structure
This protein is characterized by the presence of a domain of unknown function, DUF1640. This domain is a characteristic of the entire protein with the exception of the first twenty-three amino acid residues - MNSRQAWRLFLSQGRGDRWVSRP - which are a mitochondrial targeting site and cleaved.

The protein has seven predicted alpha helices, a characteristic of coiled-coil proteins.

Predicted Properties
Molecular Weight: 26.72 kDa

Isoelectric point: 7.5

Transmembrane Helices: None

Post-translation modifications:
 * Chloroplast transit peptides: None
 * Signal pepties: None
 * C-mannosylation sites: None
 * N-glycosylation sites: None
 * Mitochondrial targeting: Yes
 * Cleaved site: MNSRQAWRLFLSQGRGDRWVSRP

Cellular Location
CCDC90B is presumably a mitochondrial protein. It is predicted to contain at least three specific phosphorylation sites: Protein Kinase C Phosphorylation sites, Casein Kinase II Phosphorylation sites, and cAMP/cGMP Dependent Phosphorylation sites.