CRLF3

Cytokine receptor-like factor 3 is a protein that in humans is encoded by the CRLF3 gene.

Function
Although CRLF3 signaling pathways have not yet been fully characterized it is very likely that CRLF3 is a neuroprotective erythropoietin receptor.

Origin
Phylogenetic analyses have shown that CRLF3 at first appeared in a common ancestor of Cnidaria and Bilateria and hence emerged with the origin of the nervous system.