Category:Human 2OG oxygenases

Human Alpha-ketoglutarate-dependent hydroxylases are involved in a wide range of biological and medicinal processes. Enzymes of the family of Fe(II) and 2OG-dependent oxygenases couple the oxidation of their prime substrate to that of 2OG. Structurally, they share a common double-stranded beta-helix (DSBH) fold and coordinate Fe(II) by a conserved HXD/E...H triad.