Cell adhesion molecule 1

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the CADM1 gene.

Interactions
Cell adhesion molecule 1 has been shown to interact with EPB41L3.

Association studies
Genome-wide association studies identified an association between body mass index and two loci near the CADM1 and CADM2 gene. Experimental results of another study showed that obese mice had an over expression of both CADM1 and CADM2 genes, and that loss of CADM1 protected mice from obesity, promoting a negative energy balance and weight loss. Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and CADM1. In the brain, this genes mediate synaptic assembly, and mutations in CADM1 are also associated with Autistic spectrum disorder.