Cutaneous B-cell lymphoma

Cutaneous B-cell lymphomas (CBCL) constitute a group of diseases that occur less commonly than cutaneous T-cell lymphoma, and are characterized histologically by B-cells that appear similar to those normally found in germinal centers of lymph nodes. Conditions included in this group are:


 * Primary cutaneous diffuse large B-cell lymphoma, leg type
 * Primary cutaneous follicular lymphoma
 * Primary cutaneous marginal zone lymphoma
 * Intravascular large B-cell lymphoma
 * Plasmacytoma
 * Plasmacytosis

Signs and symptoms
Cutaneous B-cell lymphoma appears as single or many, often strongly consistent tumors, patches, plaques, and non-ulcerated nodules. While extracutaneous spread is a possibility, the disease usually stays restricted to the skin.

Diagnosis
Using a biopsy of the skin lesions, histological and cytological analyses, as well as phenotypic and genotypic studies, the diagnosis is made.