DNA-3-methyladenine glycosylase II

DNA-3-methyladenine glycosylase II is an enzyme    that catalyses the following chemical reaction:


 * Hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine, and 7-methyladenine

Involved in the removal of alkylated bases from DNA in Escherichia coli.

Evolution
Through the process of convergent evolution, there are at least two unrelated protein folds that share the same DNA-3-methyladenine glycosylase activity. The first, the AlkA N-terminal domain, is found in bacteria. The second, methylpurine-DNA glycosylase (MPG) is found in vertebrates including humans.

Nomenclature
DNA-3-methyladenine glycosylase II is also known as
 * deoxyribonucleate 3-methyladenine glycosides II
 * 3-methyladenine DNA glycosylase II
 * DNA-3-methyladenine glycosides II
 * AlkA
 * alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)