De Sio

De Sio is a surname of Italian origin. It may refer to:


 * Denise De Sio (b. 1952), Italian-American Lesbian Community leader
 * Giuliana De Sio (b. 1956), Italian actress
 * Teresa De Sio (b. 1955), Italian folk singer-songwriter
 * Vincenzo De Sio (b. 1972), Italian former football player