Dermatopathic lymphadenopathy

In pathology, dermatopathic lymphadenopathy, is lymph node pathology due to skin disease.

Cause
Also known as lipomelanotic reticulosis or Pautrier-Woringer disease, represents a rare form of benign lymphatic hyperplasia associated with most exfoliative or eczematoid inflammatory erythrodermas, including pemphigus, psoriasis, eczema, neurodermatitis, and atrophia senilis.

Diagnosis
Dermatopathic lymphadenopathy is diagnosed by a lymph node biopsy. It has a characteristic pattern of histomorphology and immunohistochemical staining:
 * Paracortical histiocytosis
 * Melanin-laden macrophages
 * Eosinophils
 * Plasma cells (medulla of lymph node)

Differential diagnosis

 * Cutaneous T cell lymphoma
 * Hodgkin's lymphoma
 * Melanoma

Treatment
The treatment is based on the underlying cause.