Dobrava-Belgrade orthohantavirus

Dobrava-Belgrade orthohantavirus (DOBV), also known as Dobrava virus, is an enveloped, single-stranded, negative-sense RNA virus species of Old World Orthohantavirus. It is one of several species of Hantavirus that is the causative agent of severe Hantavirus hemorrhagic fever with renal syndrome. It was first isolated in 1985 from a yellow-necked mouse (Apodemus flavicollis) found in the village of Dobrava, southeastern Slovenia. It was subsequently isolated in striped field mice in Russia and other parts of Eastern Europe. It has also been found in Germany but the reservoir host there is unknown.

Phylogeny
Four genotypes are described:
 * Dobrava, observed mostly in southeastern Europe
 * Kurkino, observed throughout northern and eastern Europe
 * Saaremaa, observed in Estonia and Slovakia
 * Sochi, observed in the Black Sea coast region of Russia

Disease
Clinical presentation varies between the four genotypes. Dobrava is the most virulent, with a case-fatality rate (CFR) of 10 to 12%, followed by Sochi, which has a CFR greater than 6%, then Kurkino, which has a CFR 0.3% to 0.9%, and lastly Saaremaa, which seems to mainly be subclinical as illness has not been reported despite a relatively high rate of seropositivity.

Natural reservoir
The four genotypes each have their own natural reservoir:
 * Dobrava: Yellow-necked mouse
 * Kurkino: Striped field mouse
 * Saaremaa: Striped field mouse
 * Sochi: Black Sea field mouse