Downtown Senatobia Historic District

The Downtown Senatobia Historic District is an approximately 7 acre historic district in Senatobia, Mississippi, U.S. It is roughly bound by North Center and South Center, North Front Street and South Front Street, West Main Street, West Tate Street and North Ward and South Ward Street. It is listed on the National Register of Historic Places since March 31, 1994.

The Downtown Senatobia Historic District includes most of the traditional central business district area in the city of Senatobia, and sixty-one principal buildings which make up the district. The downtown developed in 1856 after the opening of the Tennessee and Mississippi Railroad. Senatobia's becoming the county seat in 1873 for the newly formed county.