Edgewood Arsenal human experiments

From 1948 to 1975, the U.S. Army Chemical Corps conducted classified human subject research at the Edgewood Arsenal facility in Maryland. The purpose was to evaluate the impact of low-dose chemical warfare agents on military personnel and to test protective clothing, pharmaceuticals, and vaccines. A small portion of these studies were directed at psychochemical warfare and grouped under the prosaic title of the "Medical Research Volunteer Program" (1956–1975). The MRVP was also driven by intelligence requirements and the need for new and more effective interrogation techniques.

Overall, about 7,000 soldiers took part in these experiments that involved exposures to more than 250 different chemicals, according to the Department of Defense (DoD). Some of the volunteers exhibited symptoms at the time of exposure to these agents but long-term follow-up was not planned as part of the DoD studies. The experiments were abruptly terminated by the Army in late 1975 amidst an atmosphere of scandal and recrimination as lawmakers accused researchers of questionable ethics. Many official government reports and civilian lawsuits followed in the wake of the controversy.

The chemical agents tested on volunteers included chemical warfare agents and other related agents:


 * Anticholinesterase nerve agents (VX, sarin) and common organophosphorus (OP) and carbamate pesticides
 * Mustard agents
 * Nerve agent antidotes including atropine and scopolamine
 * Nerve agent reactivators, e.g. the common OP antidote 2-PAM chloride
 * Psychoactive agents including LSD, PCP, cannabinoids, and BZ
 * Irritants and riot control agents
 * Alcohol and caffeine

Background and rationale
After World War II, U.S. military researchers obtained formulas for the three nerve gases developed by the Nazis—tabun, soman, and sarin—and conducted studies on them at the US Army Edgewood Chemical Biological Center. These studies included a secret human subjects component at least as early as 1948, when "psychological reactions" were documented in Edgewood technicians. Initially, such studies focused solely on the lethality of the gases and its treatment and prevention. A classified report entitled "Psychochemical Warfare: A New Concept of War" was produced in 1949 by Luther Wilson Greene, Technical Director of the Chemical and Radiological Laboratories at Edgewood. Greene called for a search for novel psychoactive compounds that would create the same debilitating mental side effects as those produced by nerve gases, but without their lethal effect. In his words,"Throughout recorded history, wars have been characterized by death, human misery, and the destruction of property; each major conflict being more catastrophic than the one preceding it ... I am convinced that it is possible, by means of the techniques of psychochemical warfare, to conquer an enemy without the wholesale killing of his people or the mass destruction of his property."

In the late 1940s and early '50s, the U.S. Army worked with Harvard anesthesiologist Henry K. Beecher at its interrogation center at Camp King in Germany on the use of psychoactive compounds (mescaline, LSD), including human subject experiments and the debriefing of former Nazi physicians and scientists who had worked along similar lines before the end of the war. In the 1950s, some officials in the U.S. Department of Defense publicly asserted that many "forms of chemical and allied warfare as more 'humane' than existing weapons. For example, certain types of 'psychochemicals' would make it possible to paralyze temporarily entire population centers without damage to homes and other structures." Soviet advances in the same field were cited as a special incentive giving impetus to research efforts in this area, according to testimony by Maj. Gen. Marshall Stubbs, the Army's chief chemical officer.

General William M. Creasy, former chief chemical officer, U.S. Army, testified to the U.S. House of Representatives in 1959 that "provided sufficient emphasis is put behind it, I think the future lies in the psychochemicals." This was alarming enough to a Harvard psychiatrist, E. James Lieberman, that he published an article entitled "Psychochemicals as Weapons" in The Bulletin of the Atomic Scientists in 1962. Lieberman, while acknowledging that "most of the military data" on the research ongoing at the Army Chemical Center was "secret and unpublished", asserted that "There are moral imponderables, such as whether insanity, temporary or permanent, is a more 'humane' military threat than the usual afflictions of war."

The experiments
The Edgewood Arsenal human experiments took place from approximately 1948 to 1975 at the Medical Research Laboratories—which is now known as the U.S. Army Medical Research Institute of Chemical Defense (USAMRICD)—at the Edgewood Area, Aberdeen Proving Ground, Maryland. The experiments involved at least 254 chemical substances, but focused mainly on midspectrum incapacitants, such as LSD, THC derivatives, benzodiazepines, and BZ. Around 7,000 US military personnel and 1,000 civilians were test subjects over almost three decades. A concrete result of these experiments was that BZ was weaponized, although never deployed.

According to a DOD FAQ, the Edgewood Arsenal experiments involved the following "rough breakout of volunteer hours against various experimental categories":

An "Independent Study Course" for continuing medical education produced by the US Department of Veterans Affairs, Health Effects from Chemical, Biological, and Radiological Weapons (October 2003), presents the following summary of the Edgewood Arsenal experiments:

The "Independent Study Course" cites mainly a three-volume study by the Institute of Medicine (1982–1985) for its data and conclusions, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents. Some additional information in the section cited from the Course was based on a 1993 IOM study, Veterans at Risk: Health Effects of Mustard Gas and Lewisite.

A significant omission from the Course summary above is the number of subjects on which BZ and related compounds were tested. According to the memoirs of James Ketchum, who also cites the IOM study for the data, "24 belladonnoid glycolates and related compounds" were "given to 1,800 subjects". The IOM study also concluded that "available data suggest that long-term toxic effects and/or delayed sequellae are unlikely" for this type of compound.

In the mid-1970s, in the wake of many health claims made regarding exposure to the agents, the U.S. Congress began investigations of possible abuse in experiments and of inadequate informed consent given to the soldiers and civilians involved.

Scandal and termination
In September 1975, the Medical Research Volunteer Program was discontinued and all resident volunteers were removed from the Edgewood installation. The founder and director of the program, Van Murray Sim, was called before Congress and chastised by outraged lawmakers, who questioned the absence of follow-up care for the human volunteers. An Army investigation subsequently found no evidence of serious injuries or deaths associated with the MRVP, but deplored both the recruiting process and the informed consent approach, which they characterized as "suggest[ing] possible coercion".

Government reports
1982-85 IOM report The Institute of Medicine (IOM) published a three-volume report on the Edgewood research in 1982–1985, Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents.

The three volumes were:
 * Vol. 1, "Anticholinesterases and Anticholinergics" (1982).
 * Vol. 2, "Cholinesterase Reactivators, Psychochemicals and Irritants and Vesicants" (1984)
 * Vol. 3, "Final Report: Current Health Status of Test Subjects" (1985)

The National Academy of Sciences, which oversees the IOM, sent a questionnaire to all of the former volunteers that could be located, approximately 60% of the total. The lack of a detailed record hampered the investigation. The study could not rule out long-term health effects related to exposure to the nerve agents. It concluded that "Whether the subjects at Edgewood incurred these changes [depression, cognitive deficits, tendency to suicide] and to what extent they might now show these effects are not known". With regard specifically to BZ and related compounds, the IOM study concluded that "available data suggest that long-term toxic effects and/or delayed sequellae are unlikely".

2004 GAO report A Government Accounting Office report of May 2004, Chemical and Biological Defense: DOD Needs to Continue to Collect and Provide Information on Tests and Potentially Exposed Personnel (pp. 1, 24), stated:

"[In 1993 and 1994] we [...] reported that the Army Chemical Corps conducted a classified medical research program for developing incapacitating agents. This program involved testing nerve agents, nerve agent antidotes, psycho chemicals, and irritants. The chemicals were given to volunteer service members at Edgewood Arsenal, Maryland; Dugway Proving Ground, Utah; and Forts Benning, Bragg, and McClellan. In total, Army documents identified 7,120 Army and Air Force personnel who participated in these tests. Further, GAO concluded that precise information on the scope and the magnitude of tests involving human subjects was not available, and the exact number of human subjects might never be known."

Safety debates
The official position of the Department of Defense, based on the three-volume set of studies by the Institute of Medicine mentioned above, is that they "did not detect any significant long-term health effects on the Edgewood Arsenal volunteers". The safety record of the Edgewood Arsenal experiments was also defended in the memoirs of psychiatrist and retired colonel James Ketchum, a key scientist:

As late as 2014 incomplete information due to the failure to declassify and release relevant classified documents prevented IOM from conducting adequate medical studies related to similar former US biowarfare programs.

"The committee's understanding is that additional, and potentially relevant, material on SHAD tests exists and remains classified. The IOM committee requested declassification of 21 additional elements from at least nine documents from DoD in August 2012. In January 2014, an additional request was made for release of multiple films made of Project SHAD tests. None of the requested materials were cleared for public release as of this writing (2016)."

Even a book critical of the program, written by Lynn C. Klotz and Edward J. Sylvester, acknowledges that:

"Unlike the CIA program, research subjects [at Edgewood] all signed informed consent forms, both a general one and another related to any experiment they were to participate in. Experiments were carried out with safety of subjects a principal focus. [...] At Edgewood, even at the highest doses it often took an hour or more for incapacitating effects to show, and the end-effects usually did not include full incapacitation, let alone unconsciousness. After all, the Edgewood experimenters were focused on disabling soldiers in combat, where there would be tactical value simply in disabling the enemy."

Lawsuits
The U.S. Army believed that legal liability could be avoided by concealing the experiments. However once the experiments were uncovered, the US Senate also concluded questionable legality of the experiments and strongly condemned them."In the Army's tests, as with those of the CIA, individual rights were ... subordinated to national security considerations; informed consent and follow-up examinations of subjects were neglected in efforts to maintain the secrecy of the tests. Finally, the command and control problems which were apparent in the CIA's programs are paralleled by a lack of clear authorization and supervision in the Army's programs.(S. Rep., at 411.[5])"

In the 1990s, the law firm Morrison & Foerster agreed to take on a class-action lawsuit against the government related to the Edgewood volunteers. The plaintiffs collectively referred to themselves as the "Test Vets".

In 2009 a lawsuit was filed by veterans rights organizations Vietnam Veterans of America, and Swords to Plowshares, and eight Edgewood veterans or their families against CIA, the U.S. Army, and other agencies. The complaint asked the court to determine that defendants' actions were illegal and that the defendants have a duty to notify all victims and to provide them with health care. In the suit, Vietnam Veterans of America, et al. v. Central Intelligence Agency, et al. Case No. CV-09-0037-CW, U.S.D.C. (N.D. Cal. 2009), the plaintiffs did not seek monetary damages. Instead, they sought only declaratory and injunctive relief and redress for what they claimed was several decades of neglect and the U.S. government's use of them as human guinea pigs in chemical and biological agent testing experiments.

The plaintiffs cited:


 * The use of troops to test nerve gas, psychochemicals, and thousands of other toxic chemical or biological substances.
 * A failure to secure informed consent and other widespread failures to follow the precepts of U.S. and international law regarding the use of human subjects, including the 1953 Wilson Directive and the Nuremberg Code.
 * A refusal to satisfy their legal and moral obligations to locate the victims of experiments or to provide health care or compensation to them
 * A deliberate destruction of evidence and files documenting their illegal actions, actions which were punctuated by fraud, deception, and a callous disregard for the value of human life.

On July 24, 2013, United States District Court Judge Claudia Wilken issued an order granting in part and denying in part plaintiffs' motion for summary judgment and granting in part and denying in part defendants' motion for summary judgment. The court resolved all of the remaining claims in the case and vacated trial. The court granted the plaintiffs partial summary judgment concerning the notice claim: summarily adjudicating in plaintiffs' favor, finding that "the Army has an ongoing duty to warn" and ordering "the Army, through the DVA or otherwise, to provide test subjects with newly acquired information that may affect their well-being that it has learned since its original notification, now and in the future as it becomes available". The court granted the defendants' motion for summary judgment with respect to the other claims.

On appeal in Vietnam Veterans of America v. Central Intelligence Agency, a panel majority held in July 2015 that Army Regulation 70-25 (AR 70-25) created an independent duty to provide ongoing medical care to veterans who participated in U.S. chemical and biological testing programs. The prior finding held that the Army has an ongoing duty to seek out and provide "notice" to former test participants of any new information that could potentially affect their health.

List of notable EA (Edgewood Arsenal) numbered chemicals

 * EA 1152 - Diisopropyl fluorophosphate (DFP)
 * EA 1205 - Tabun (GA)
 * EA 1208 - Sarin (GB)
 * EA 1210 - Soman (GD)
 * EA 1212 - Cyclosarin (GF)
 * EA 1285 - Tetraethyl pyrophosphate (TEPP)
 * EA 1298 - Methylenedioxyamphetamine (MDA), an analogue and active metabolite of MDMA
 * EA 1508 - VG
 * EA 1517 - VE
 * EA 1653 - LSD in tartrate form
 * EA 1664 - Edemo (VM)
 * EA 1701 - VX
 * EA 1729 - LSD in free base form
 * EA 1779 - CS gas
 * EA 2092 - Benactyzine
 * EA 2148-A - Phencyclidine (PCP)
 * EA 2233 - A dimethylheptylpyran variant
 * Eight individual isomers numbered EA-2233-1 through EA-2233-8
 * EA 2277 - BZ ("Substance 78" to Soviets)
 * EA 3148 - A "V-series" nerve agent, Cyclopentyl S-2-diethylaminoethyl methylphosphonothiolate ("Substance 100A" to Soviets)
 * EA 3167 - A BZ variant
 * EA 3443 - A BZ variant
 * EA 3528 - LSD in maleate form
 * EA 3580 - A BZ variant
 * EA 3834 - A BZ variant
 * EA-4929 - An enantiomer of the drug Dexetimide, also known as benzetimide
 * EA 4942 - Etonitazene in free base form
 * EA 5365 - GV
 * EA 5823 - Sarin (GB) as a binary agent from mixing OPA (isopropyl alcohol+isopropyl amine) + DF

General sources

 * Two autobiographical books from psychiatrists conducting human experiments at Edgewood have been self-published:
 * Men and Poisons: The Edgewood Volunteers and the Army Chemical Warfare Research Program (2005), Xlibris Corporation, 140pp, was written by Malcolm Baker Bowers Jr, who went on to become a prof of psychiatry at Yale. Bowers' book is a "fictionalized" account with names changed.
 * Chemical Warfare Secrets Almost Forgotten, A Personal Story of Medical Testing of Army Volunteers with Incapacitating Chemical Agents During the Cold War (1955–1975) (2006, 2nd edition 2007), foreword by Alexander Shulgin, ChemBook, Inc., 360 pp, was written by Ketchum who was a key player after 1960 and went on to become a professor at the University of California, Los Angeles.
 * The Vanderbilt University Television News Archive has two videos about the experiments, both from a July 1975 NBC Evening News segment.
 * NBC newsman John Chancellor reported on how Norman Augustine, then-acting Secretary of Army, ordered a probe of Army use of LSD in soldier and civilian experiments.
 * Correspondent Tom Pettit reported on Major General Lloyd Fellenz, from Edgewood Arsenal, who explained how the experiments there were about searching for humane weapons, adding that the use of LSD was unacceptable.
 * Journalist Linda Hunt, citing records from the U.S. National Archives, revealed that eight German scientists worked at Edgewood, under Project Paperclip. Hunt used this finding to assert that in this collaboration, US and former Nazi scientists "used Nazi science as a basis for Dachau-like experiments on over 7,000 U.S. soldiers".
 * A The Washington Post article, dated July 23, 1975, by Bill Richards ("6,940 Took Drugs") reported that a top civilian drug researcher for the Army said a total of 6,940 servicemen had been involved in Army chemical and drug experiments, and that, furthermore, the tests were proceeding at Edgewood Arsenal as of the date of the article.
 * Two TV documentaries, with different content but confusingly similar titles were broadcast:
 * Bad Trip to Edgewood (1993) on ITV Yorkshire
 * Bad Trip to Edgewood (1994) on A&E Investigative Reports.
 * In 2012, the Edgewood/Aberdeen experiments were featured on CNN and in The New Yorker magazine.