GHKL domain

The GHKL domain (Gyrase, Hsp90, Histidine Kinase, MutL) is an evolutionary conserved protein domain. It is an ATPase domain found in several ATP-binding proteins such as histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90,  phytochrome-like ATPases and DNA mismatch repair proteins.

More information about this protein can be found at Protein of the Month: DNA Topoisomerase.

Structure
The fold of this domain consists of two layers, alpha/beta, which contain an 8-stranded mixed beta-sheet.

Subfamilies

 * Heat shock protein Hsp90, N-terminal


 * Sensor histidine kinase NatK, C-terminal domain

Members

 * BCKDK
 * HSP90AA1, HSP90AB1, HSP90B1
 * MLH1, MLH3, MORC1, MORC2, MORC3, MORC4
 * PDK1, PDK2, PDK3, PDK4
 * PMS1, PMS2, PMS2L1, PMS2L11, PMS2L3, PMS4L
 * TOP2A, TOP2B
 * TRAP1, TRRAP