Growth delay-hydrocephaly-lung hypoplasia syndrome

Growth delay-hydrocephaly-lung hypoplasia syndrome, also known as Game-Friedman-Paradice syndrome is a very rare hereditary disorder which is characterized by developmental, lung, and brain anomalies. Only 4 cases have been reported in medical literature.

Signs and symptoms
The following is a list of the symptoms usually shown by fetuses with the disorder:


 * Delayed fetal growth
 * Hydrocephaly
 * Sylvius patent aqueduct
 * Micrognathia
 * Poorly developed (hypoplastic) lungs
 * Malrotated intestines
 * Omphalocele
 * Shortening of the lower limbs
 * Tibia bowing
 * Generalized foot abnormalities

History
It was first discovered in 1989, by Game et al. when they described 4 fetus siblings (3 females, 1 male) born to healthy, non-consanguineous parents with all the symptoms mentioned above. The siblings were terminated and all of them (post-mortem examination) had a size similar to fetuses of younger gestational age.