Holy Family Catholic Church Historic District

The Holy Family Catholic Church Historic District, in Natchez, Mississippi, is a 9.2 acre historic district that was listed on the U.S. National Register of Historic Places (NRHP) in 1995.

Its most significant building is the Holy Family Church, the first African-American Catholic church in the state, dedicated in 1894 and staffed by the Josephites. It is Natchez's best piece of Gothic Revival architecture. The district as a whole is significant for its architecture and for its African-American historical associations.

The listing included 49 contributing buildings and one other contributing site. It includes Greek Revival, Italianate, and Queen Anne architecture.

The area is a historically black neighborhood. The district is a cluster of buildings near to the Holy Family Catholic Church, which is on St. Catherine St., which was originally the old Natchez Trace.