Intra-ampullary papillary–tubular neoplasm

Intra-ampullary papillary–tubular neoplasms (IAPN) are precancerous neoplasms of the ampulla of Vater. On histological examination the neoplasms exhibit both papillary and tubular features.

IAPN were first described in 2010. They are rare; comprising 0.5% of gastrointestinal tumours.