Isaac Guerendo

Isaac Guerendo (born June 28, 2000) is an American football running back for the San Francisco 49ers of the National Football League (NFL). He previously played college football for the Wisconsin Badgers and Louisville Cardinals.

Early life and high school
Guerendo was born in Clayton, Indiana and attended Avon High School in Avon, Indiana. In his junior season, Guerendo hauled in 19 receptions for 596 yards and six touchdowns. Guerendo had a breakout senior season bringing in 54 receptions for 1,258 yards and 16 touchdowns. As a senior, Guerendo was named the Indianapolis Star's Mister Football for wide receivers.

Coming out of high school, Guerendo decided to commit to play college football for the Wisconsin Badgers.

Wisconsin
In Guerendo's first season in 2019, he carried the ball once for one yard, while also making one catch for three yards, and returning one kickoff for 49 yards. In the COVID shortened 2020 season, Guerendo carried the ball 11 times for 36 yards. In week two of the 2021 season, he recorded his first career touchdown on an 82-yard run versus Eastern Michigan. Guerendo finished the 2021 season with 160 yards and a touchdown of 23 carries, while also racking up two receptions for six yards. In 2022 he rushed for 385 yards and five touchdowns on 64 carries, while also notching 17 receptions for 115 yards and a touchdown. After the conclusion of the 2022 season, Guerendo decided to enter the NCAA transfer portal.

Guerendo finished his Wisconsin Badger career playing in 20 games carrying the ball 99 for 582 yards and six touchdowns, while also notching 20 receptions for 124 yards and a touchdown.

Louisville
Guerendo decided to transfer to play for the Louisville Cardinals. In Guerendo's Louisville home debut in week two of the 2023 season, he rushed for 63 yards and a touchdown on 11 carries, while also hauling in four receptions for 47 yards. In week ten of the 2023 season, Guerendo had a career performance rushing for 146 yards and three touchdowns in a win over Virginia Tech. In the 2023 Holiday Bowl, Guerendo rushed for a career high 161 yards and three touchdowns, on 23 carries, but the Cardinals lost to USC 42-28. Guerendo finished the 2023 season with 810 yards and 11 touchdowns on 132 carries, while also making 22 receptions for 234 yards. After the conclusion of the 2023 season, Guerendo declared for the 2024 NFL draft.

Professional career
Guerendo was drafted by the San Francisco 49ers in the 4th round (129th overall) of the 2024 NFL Draft.

Personal
Isaac was born in Indianapolis to Mario and Jennifer Guerendo. Mario is an immigrant from the Central African Republic, and Jen competed in track & field in high school. While some assume the family surname is Hispanic, it is of African origin.