Isoflavonoid biosynthesis

The biosynthesis of isoflavonoids involves several enzymes; These are:

Liquiritigenin,NADPH:oxygen oxidoreductase (hydroxylating, aryl migration), also known as Isoflavonoid synthase, is an enzyme that uses liquiritigenin (a flavanone), O2, NADPH and H+ to produce 2,7,4'-trihydroxyisoflavanone (an isoflavonoid), H2O and NADP+.


 * Biochanin-A reductase
 * Flavone synthase
 * 2'-hydroxydaidzein reductase
 * 2-hydroxyisoflavanone dehydratase
 * 2-hydroxyisoflavanone synthase
 * Isoflavone 4'-O-methyltransferase
 * Isoflavone 7-O-methyltransferase
 * Isoflavone 2'-hydroxylase
 * Isoflavone 3'-hydroxylase
 * Isoflavone-7-O-beta-glucoside 6"-O-malonyltransferase
 * Isoflavone 7-O-glucosyltransferase
 * 4'-methoxyisoflavone 2'-hydroxylase

Pterocarpans biosynthesis

 * 3,9-dihydroxypterocarpan 6a-monooxygenase
 * Glyceollin synthase
 * Pterocarpin synthase